Generation of Biological Samples Positive to Hydrochlorothiazide for Anti-doping Control

Inclusion Criteria: * Male volunteers aged between 18 and 45 years. * Able to understand and accept the trial procedures and able to sign an informed consent. * History and physical examination that demonstrate not presenting organic or psychiatric disorders. * ECG, blood and urine tests performed at screening should be within normal limits. Minor or punctual variations of these limits of normality are admitted if, in the opinion of the Principal Investigator, they have no clinical significance, do not pose a risk to the subject and do not interfere with the evaluation of the product in study. These variations and their non-relevance will be justified in writing specifically. * Body mass index (weight/size\^2) between 19 and 26 kg/m2, and weight between 50 and 90 kg. Subjects with BMI \>26 kg/m2 may be included at the discretion of the Principal Investigator. Exclusion Criteria: * Failure to meet the inclusion criteria. * History of allergy, idiosyncrasy, hypersensitivity or adverse reactions to the active substance or any of the excipients. History of serious adverse reactions to other medications. * Subjects with contraindications to treatment with the study drug (according to Summary of Product Characteristics). * Background or clinical evidence of psychiatric disorders, alcoholism, regular consumption of psychoactive drugs, drug abuse or addiction to other substances (except for nicotine). Smokers of more than 5 cigarettes/day will be excluded. * Having participated in another clinical trial with medication in the three months prior to the start of the study. * Having donated blood during the month prior to the start of the study. * Having suffered an organic disease or major surgery in the three months prior to the start of the study. * Background or clinical evidence of cardiovascular, respiratory, renal, hepatic, endocrine, gastrointestinal, hematological, neurological, dermatological or other acute or chronic diseases that, in the opinion of the Principal Investigator or the collaborators designated by him, may pose a risk to the subjects, may interfere with the objectives of the study or may alter the pharmacokinetics of the drug. * Have taken medication regularly in the month prior to the study sessions, with the exception of vitamins, herbal remedies or dietary supplements that, in the opinion of the Principal Investigator or the collaborators designated by him, do not pose a risk to the subjects and do not interfere with the objectives of the study. Treatment with single doses of symptomatic medication in the week prior to the study sessions will not be exclusive if it is assumed that medication has been completely eliminated on the day of the experimental session. * Consumption of more than 15 g of alcohol per day. * Consumers of more than 3 coffees, teas, cola drinks and/or other stimulant drinks (xanthines) per day in the month prior to the start of the study. * Being unable to understand the nature of the trial and the procedures requested to follow. * Positive serology for hepatitis B, C or HIV.