The present clinico-biochemical study was carried out to estimate the levels of Fetuin A and MMP7 in serum of systemically healthy subjects in periodontal health and disease and to evaluate the impact of periodontal interventional therapy (scaling and root planing) on the same.
Sixty sex-matched subjects (30 males and 30 females) belonging to a common age group (30-39 yrs) were enrolled for the study to eliminate bias from confounding factors. They were divided into three groups consisting of 20 subjects in each group based on the clinical and radiological parameters; Periodontally healthy (Group I), Chronic gingivitis (Group II) and chronic periodontitis ( Group IIIa) from whom serum samples were collected. The Group IIIb further comprised of the subjects from Group IIIa, who had received non-surgical periodontal therapy (scaling and root planing). Serum samples were collected at baseline and at 12 weeks post therapy. Fetuin A and MMP-7 concentration was determined from serum samples of patients using ELISA. The results of our study depicted that Fetuin A concentration negatively correlates, whereas, MMP7 positively correlates with the extent of periodontal inflammation. Further, Periodontal therapy demonstrated a significant increase in serum Fetuin A and decrease in MMP 7 levels establishing the influence of periodontal therapy in stabilizing their levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Procedure/Surgery: non surgical periodontal therapy and root planing (SRP) was performed in two to four appointments lasting approximately 60 minutes each under local anaesthesia (2% lignocaine hydrochloride with 1:2,00,000 adrenaline) using area specific Gracey periodontal curettes and an ultrasonic device. The treatment was concluded in 3 months. Within the duration of the study, all subjects received supportive therapy, which included professional plaque control and reinstruction of oral hygiene.
Krishnadevaraya college of dental sciences
Bangalore, Karnataka, India
estimate the change in levels of Fetuin A and MMP7 in serum at baseline and 3 months post SRP
Serum was collected at baseline and 3 months and subjected to ELISA
Time frame: Serum collection at baseline and 3 months
Modified Gingival index (GI)
The index was recorded at only baseline for healthy and gingivitis groups and at baseline and 3 months post therapy for periodontitis group
Time frame: At baseline and 3 months
Relative Attachment level (RAL)
The index was recorded at only baseline for healthy and gingivitis groups and at baseline and 3 months post therapy for periodontitis group
Time frame: At baseline and 3 months
Probing Depth (PD)
The index was recorded at only baseline for healthy and gingivitis groups and at baseline and 3 months post therapy for periodontitis group
Time frame: At baseline and 3 months
Bleeding on Probing (BOP%)
The index was recorded at only baseline for healthy and gingivitis groups and at baseline and 3 months post therapy for periodontitis group
Time frame: At baseline and 3 months
Plaque index (PI)
The index was recorded at only baseline for healthy and gingivitis groups and at baseline and 3 months post therapy for periodontitis group
Time frame: At baseline and 3 months
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