This study prospectively recruited esophageal squamous-cell carcinoma patients who received nasogastric tube (NG), gastrostomy feeding and oral intake to compare the changes in nutritional status and quality of life during chemoradiation therapy (CRT).
Study Type
OBSERVATIONAL
Enrollment
156
Dietary guidance for feeding tube patients with food homogenate,dietary guidance for patients with oral feeding.
Department of Radiation Oncology, Tianjin Medical University cancer Institute and Hospital
Tianjin, Tianjin Municipality, China
Body Weight Change from baseline to the end of treatment
Body weight change from baseline to the end of treatment = body weight at the end of treatment - baseline body weight.
Time frame: up to 1 month after the treatment
Blood biochemical examination
albumin,prealbumin,haemoglobin,et al, record the changes before and after the treatment.
Time frame: up to 1 month after the treatment
Scored Patient-Generated Subjective Global Assessment (PG-SGA)
Nutritional status evaluation table. score: 0-1 A: well-nourished; score:2-8 B: moderately malnourished; score:≥9 C: severely malnourished.
Time frame: up to 1 month after the treatment
EORTC QLQ-C30
Quality of life evaluation form. QLQ-C30 results were linearly transformed to scores 0 to 100. Higher scores represent worse symptoms in the symptom scales and better function in functional scales.
Time frame: up to 1 month after the treatment
Grade 3-5 toxicity
Grade 3-5 adverse events as assessed by NCI Common Toxicity Criteria for Adverse Effects (CTCAE) v3.0 andthe criteria of the Radiation Therapy Oncology Group ,such as esophagitis、pneumonitis 、hematologic toxicity and infection rate
Time frame: up to 1 month after the treatment
Completion rate of chemoradiotherapy
The proportion of people who complete all treatment as required
Time frame: up to 1 month after the treatment
Overall Survival
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overall survival
Time frame: at least 2 years