A Clinical Study to Evaluate the Safety and Efficacy of OrienX010 in Unresectable Malignant Melanoma Patients

Inclusion Criteria: 1. Obtain the current IRB approved informed consent with written from potential patients before the any screening activities or procedures. 2. Male or female, ≥ 18 years and ≤ 70 years of age. 3. Patients with histologically proven unresectable stage IIIb /IIIc or IV (M1a/M1b) malignant melanoma following AJCC edition 8 published 2016 guidance. If patient in stage IV (M1b), pulmonary lesion as following: number of pulmonary lesion must be ≤ 5; any single lesion must less than 20 mm in longest diameter; total cumulative diameter of all lesions must be ≤ 50 mm; 4. Patients with at least one measurable lesion with size ≥ 10 mm and \< 100mm. 5. Patient with at least one injectable lesion (long diameter ≥ 10 mm and \< 100mm 6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. 7. Patients with life expectancy \> 5 months as judged by investigator. 8. Patients with adequate bone marrow, liver and renal function within 28 days prior to study entry, as defined by the following: * White Blood Cell count ≥3.0 × 109/L * Absolute neutrophil count (ANC) ≥ 1.5 × 109/L * Platelet count≥ 100 × 109/L * Hemoglobin \> 10.0 g/dl. * Albumin ≥ 3 g/dl. * liver function: Total bilirubin ≤ 1.5 x upper normal limit (UNL) , Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \< 2.5 x upper normal limit (UNL). * renal function: serum creatinine \< 1.5 x UNL or 24 hour creatinine clearance rate≥ 50 mL/min（calculated by Cockcroft and Gault） * International normalized ratio (INR) \< 1.5 and Activated partial thromboplastin time (APTT) or Partial thromboplastin time (PTT) ≤ 1.5 × ULN 9. Subjects who have received any anti-cancer therapy, including radiotherapy, cytotoxic, hormonal, biological (including humanized antibodies) and targeted agents within 28 days, or five half-lives of the drug (whichever is longer) prior to randomization and not recovered from acute toxicities as a result of prior anti-cancer therapy to less than or equal to Grade 1, according to Common Terminology Criteria for Adverse Events (CTCAE, version 4.03). 10. Women of childbearing potential （early menopause, Post-menopause \< 2 years and non- sterilization）, Man and man with female partner of childbearing potential should be use effective contraception during the study period , e.g. sterilization, progestogen oral contraceptives, injectable progestogen, implants of levonorgestrel, oestrogenic vaginal ring, percutaneous contraceptive patches or intrauterine device (IUD) or intrauterine system (IUS), abstinence or or double barrier method (condom or occlusive cap plus spermicidal agent). Exclusion Criteria: 1. Patients that have previously been treated with dacarbazine. 2. Previous treatment with any investigational product or T-VEC or other similar ' oncolytic' viruses therapy. 3. Sizes of tumor does not meet the requirement of injection or unacceptable for intratumoral injection. 4. Patients who have treatment with anti-HSV antiviral therapy (such as acyclovir, ganciclovir, foscarnet, etc.) within 4 weeks prior to the first IP administration. 5. No history of malignancy within the past 5 years except for the following: adequately treated of stage I or II basal cell/squamous cell skin cancer, superficial bladder cancer or any other cancer from which the patient has been completed curative therapy. 6. Patients with known or suspected allergies and/or hypersensitivity to any component of OrienX10 or Dacarbazine. 7. HSV - 1 antibody IgG and IgM are negative 8. Positive test for hepatitis B virus surface antigen (HBVsAg) and HBV DNA copies \>1x103copies /mL. 9. Positive test for hepatitis C and Human Immunodeficiency Virus (HIV) Patients with clinically evident Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) infection. 10. Patient with uncontrolled systemic illness including, but not limited to, serious infection, uncontrolled, diabetes, unstable angina, cerebrovascular accidents or transient ischaemic attack, myocardial infarction, congestive heart failure, clinically significant arrhythmias not controlled by medication, liver, kidney or metabolic disease. 11. Patient with autoimmune diseases. 12. Patient has psychological or psychiatric disorder or alcohol dependence or Drug addiction which would increase risk or limit compliance with study requirements or influence the study result. 13. Use of any investigational drugs, biologics, or devices within 30 days prior to screening visit or planned use during the course of study. 14. Pregnant or breastfeeding women or women desiring to become pregnant within the timeframe of the study or women/men of reproductive potential not using an effective contraception. 15. Any condition, judged by investigator, that shows subjects are not suitable for participation