SGLT2 Inhibitor Adjunctive Therapy to Closed Loop Control in Type 1 Diabetes Mellitus

Inclusion Criteria: 1. Age ≥18.0 and ≤65 years old at time of consent 2. Clinical diagnosis, based on investigator assessment, of type 1 diabetes for at least one year 3. Currently using an insulin pump for at least six months 4. Currently using insulin for at least six months 5. Using insulin parameters such as carbohydrate ratio and correction factors consistently on their pump in order to dose insulin for meals or corrections 6. Access to internet and willingness to upload data during the study as needed 7. For females, not currently known to be pregnant or breastfeeding 8. If female and sexually active, must agree to use a form of contraception to prevent pregnancy while a participant in the study. A negative serum or urine pregnancy test will be required for all females of childbearing potential. Participants who become pregnant will be discontinued from the study. Also, participants who during the study develop and express the intention to become pregnant within the timespan of the study will be discontinued. 9. Willingness to suspend use of any personal CGM for the duration of the clinical trial once the study CGM is in use 10. Willingness to switch to lispro (Humalog) or aspart (Novolog) if not using already, and to use no other insulin besides lispro (Humalog) or aspart (Novolog) during the study 11. Total daily insulin dose (TDD) at least 10 U/day 12. Willingness not to start any new non-insulin glucose-lowering agent during the course of the trial (including metformin, GLP-1 agonists, pramlintide, DPP-4 inhibitors, biguanides, sulfonylureas and naturaceuticals) 13. Willingness to eat at least 100 grams of carbohydrates per day 14. An understanding and willingness to follow the protocol and signed informed consent 15. Pilot Participants: Agree to hotel/research house admission with other Pilot participants on a date selected by the study team. Exclusion Criteria: 1. Hemoglobin A1c \>9% 2. History of diabetic ketoacidosis (DKA) in the 12 months prior to enrollment 3. Severe hypoglycemia resulting in seizure or loss of consciousness in the 12 months prior to enrollment 4. Pregnancy or intent to become pregnant during the trial 5. Currently breastfeeding or planning to breastfeed 6. Currently being treated for a seizure disorder 7. Planned surgery during study duration 8. History of cardiac arrhythmia (except for benign premature atrial contractions and benign premature ventricular contractions which are permitted) 9. Clinically significant electrocardiogram (ECG) abnormality at time of Screening, as interpreted by the study medical physician 10. Use of diuretics (e.g. Lasix, Thiazides) 11. History of chronic or recurrent genital infections 12. eGFR lab value below 60 mL/min/1.73 m2 13. Treatment with any non-insulin glucose-lowering agent (including metformin, GLP-1 agonists, pramlintide, DPP-4 inhibitors, SGLT-2 inhibitors, biguanides, sulfonylureas and naturaceuticals) 14. A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as the following examples: 1. Severe renal impairment, end-stage renal disease, or dialysis 2. Inpatient psychiatric treatment in the past six months 3. Presence of a known adrenal disorder 4. Abnormal liver function test results (Transaminase\>2 times the upper limit of normal); testing required for subjects taking medications known to affect liver function or with diseases known to affect liver function 5. Uncontrolled thyroid disease 15. Severe renal impairment, end-stage renal disease, or dialysis 16. Use of an automated insulin delivery mechanism that is not downloadable by the subject or study team 17. Current enrollment in another clinical trial, unless approved by the investigator of both studies or if clinical trial is a non-interventional registry trial 18. Alcohol restricted to no more than 2 drinks per night in men and no more than 1 drink per night in women 19. Low carb diet (less than 100g per day)