Immunologic Biomarker Profile of Cerebrospinal Fluid

N/ACompletedNCT04202055

Centre Hospitalier Universitaire de Nīmes165 enrolled

Overview

The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients

Study Type

OBSERVATIONAL

Enrollment

165

Conditions

Multiple Sclerosis Neuromyelitis Optica

Interventions

Biomarker analysisOTHER

Detection of biomarker in cerebrospinal fluid

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients who have had neuromyelitis ptica with anti-AQP4 antibodies, or anti- Myelin Oligodendrocyte Glycoprotein antibodies, or double seronegative antibodies. * Neuromyelitis Optica patients have been prospectively included in the OFSEP collection * Multiple sclerosis patients, isolated myelitis or optic neuritis patients, and symptomatic controls whose samples will come from the "NEURO" collection of the Hospital Biological Collections Center, * Patients have given their free consent for use of their samples in research

Locations (1)

CHU de Nimes

Nîmes, France

Outcomes

Primary Outcomes

Level of glial fibrillar acidic protein in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of chitinase-3-like protein 1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of neurofilament in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin-6 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin-8 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Matrix metalloproteinase-9 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Soluble CD27 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein

Data from ClinicalTrials.gov

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Secondary Outcomes

Level of glial fibrillar acidic protein in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of chitinase-3-like protein 1 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of neurofilament in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin-6 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin-8 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Matrix metalloproteinase-9 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Soluble CD27 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin 10 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin 17A in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of Interleukin 1B in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline

Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in each group

enzyme-linked immunosorbent assay

Time frame: Baseline