Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial)

Inclusion Criteria: * STEMI \< 12 hours undergoing primary PCI. * ST-segment elevation of \> 1mm in \> 2 contiguous leads, or (presumably new) left bundle branch block, or true posterior MI with ST depression of \>1mm in \>2 contiguous anterior leads. * Presence of at least one acute infarct artery target vessel with one or more de-novo coronary artery stenosis in a native coronary artery within 2.75 - 3.75 mm reference vessel diameter and \< 24 mm length (visually estimated). Exclusion Criteria: * Inability to provide informed consent * Female of childbearing potential (age \<50 years and last menstruation within the last 12 months), who did not undergo tubal ligation, ovariectomy or hysterectomy * Known intolerance to aspirin, heparin, PLLA, everolimus, contrast material * Cardiogenic Shock * Unprotected left main coronary artery stenosis * Distal occlusion of target vessel * Acute myocardial infarction secondary to stent thrombosis * Mechanical complications of acute myocardial infarction * Severe tortuous, calcified or angulated coronary anatomy of the study vessel that in the opinion of the investigator would result in sub-optimal imaging or excessive risk of complication in the follow-up procedure * Active bleeding or coagulopathy or patients at chronic anticoagulation therapy * Chronic renal dysfunction with creatinine clearance \< 45 ml/minm2 * Subject is currently participating in another clinical trial that has not yet completed its primary endpoint