Improving Neuroprotective Strategy for Ischemic Stroke With Sufficient Recanalization After Thrombectomy by Intra-arterial Cocktail Therapy (INSIST-CT)

Inclusion Criteria: 1. Age ≥18 years. 2. Patients who presented with acute ischemic stroke and a large vessel occlusion in the anterior circulation and met the criteria of mechanical thrombectomy. 3. Sufficient recanalization （TICI 2b-3）within 7 hours of stroke onset. 4. The availability of informed consent. Exclusion Criteria: 1. insufficient recanalization（TICI \< 2a）after endovascular treatment; 2. Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage. 4\. Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ \<100000/mm3）. 5\. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis. 6\. Severe uncontrolled hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg). 7\. Patients with contraindication or allergic to any ingredient of drugs in our study. 8\. Unsuitable for this clinical studies assessed by researcher.