The aim of this study is to adjust the end tidal inhalation anesthetic concentration by observing the entropy value in patients who will be provided anesthesia maintenance with volatile anesthetics after applying the routine epidural anesthesia technique and to observe the end tidal volatile concentration that will provide to remain in the target entropy limits during the operation.
The hypothesis of this study is that in general anesthesia cases which is combined with thoracic epidural anesthesia (TEA), lower alveolar concentration will be required to reach the same anesthesia depth. The main aim of the study is observing and comparing the alveolar concentrations of anesthetic agents with entropy monitoring which is an anesthesia depth monitor in major abdominal surgeries where general anesthesia is combined or not with TEA. In cases where TEA is combined with general anesthesia or not, anesthesia depth will be effectively monitored by entropy monitoring, in this way the adequate depth of anesthesia will be provided with the use of minimal volatile anesthetics and we will be able to prevent the use of large amounts of volatile anesthetics., It will be determined how much reduction in alveolar concentration is required in cases combined with TEA. Nowadays, with the development of reliable anesthesia machines, "low-flow anesthesia" (LFA) is becoming more widespread, and its benefits on patient health, economy and ecology have been demonstrated. In LFA, the depth of anesthesia should not be too superficial or too deep during the time the alveolar concentration of volatile agent reaches equilibrium. Therefore, alveolar concentrations of volatile anesthetics are monitored in modern anesthesia machines. Some machines may also adjust the depth of anesthesia according to the alveolar concentration of the agent.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
DOUBLE
Enrollment
44
%0.25 bupivacaine solution
End tidal sevoflurane concentration
İstanbul University
Istanbul, Turkey (Türkiye)
End tidal volatile anesthetic concentration
End tidal volatile anesthetic concentration that keeps entropy in normal limits
Time frame: up to 20 minutes
Total volatile anesthetic consumption
Amount of total inhalation anesthetic consumed during surgery
Time frame: up to 2 hours
Time to reach target concentration
Time to reach the end tidal anesthetic concentration that we set
Time frame: up to 10 minutes
Inhalation anesthetic amount the target concentration reached ( in the period of reaching the set alveolar concentration)
The amount of inhalation anesthetic consumed until reaching the target concentration
Time frame: up to 5 minutes
The amount of propofol
The amount of using propofol for anesthesia induction
Time frame: 2 minutes
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