The overall aim of this study is to investigate whether a diet rich in rye fiber from wholegrain rye, compared to refined wheat, as part of a hypo-caloric diet leads to larger weight loss and lower body fat content after 12 weeks of intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
255
Participants will receive a fixed amount of rye based cereals products, corresponding to approx 650 kcal/day.
Participants will receive a fixed amount of wheat based cereals products, corresponding to approx 650 kcal/day.
Chalmers University of Technology
Gothenburg, Sweden
Investigate if there is a difference in body weight at week 12
Measured on a scale
Time frame: 12 weeks
Investigate if there is a difference in body fat mass at week 12
Measured by dual energy x-ray absorptiometry
Time frame: 12 weeks
Investigate if there are differences in subjective appetite ratings
Measured by visual analogue scale (assessing hunger fullness and desire to eat), throughout a whole day (8:00-21:00), at baseline, week 6 and week 12.
Time frame: 0 weeks, 6 weeks and 12 weeks.
Investigate if differences in primary endpoints (body weight) are apparent at week 6
Measured on a scale
Time frame: 6 weeks
Investigate if differences in primary endpoints (fat mass) are apparent at week 6
Measured by dual energy x-ray absorptiometry
Time frame: 6 weeks
Investigate if lean body mass differs between intervention groups after 6 and 12 weeks of intervention
Measured by dual energy x-ray absorptiometry
Time frame: 6 weeks and 12 weeks
Investigate if abdominal fat mass differs between intervention groups after 6 and 12 weeks of intervention
Measured by dual energy x-ray absorptiometry
Time frame: 6 weeks and 12 weeks
Investigate if fasting plasma triglycerides differ between groups
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Time frame: 6 weeks and 12 weeks
Investigate if fasting plasma low-density lipoprotein cholesterol differ between groups
Time frame: 6 weeks and 12 weeks
Investigate if fasting plasma high-density lipoprotein cholesterol differ between groups
Time frame: 6 weeks and 12 weeks
Investigate if fasting plasma total cholesterol differ between groups
Time frame: 6 weeks and 12 weeks
Investigate if fasting plasma glucose differ between groups
Time frame: 6 weeks and 12 weeks
Investigate if fasting serum insulin differ between groups
Time frame: 6 weeks and 12 weeks
Investigate if C-reactive protein differ between groups
Time frame: 6 weeks and 12 weeks
Investigate if gut microbiota composition is affected by the intervention
Gut microbiota composition will be analyzed using 16S ribosomal ribonucleic acid (rRNA) sequencing
Time frame: 6 weeks and 12 weeks
Investigate if hip circumference differ between intervention groups
Time frame: 6 weeks and 12 weeks
Investigate if waist circumference differ between intervention
Time frame: 6 weeks and 12 weeks
Investigate if sagittal height differ between intervention groups
Time frame: 6 weeks and 12 weeks