A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma

Key Inclusion Criteria: * A physician diagnosis of asthma * Pre-bronchodilator FEV1 between 30% and 75% predicted at both the screening and baseline visits * Bronchodilator reversibility defined as \>200 mL and 12% increase in FEV1 post-administration of a short-acting beta agonist (SABA). A patient may also qualify if there is a documented history of bronchodilator reversibility or positive methacholine challenge test within 12 months prior to the screening visit * Stable background therapy for at least 3 months with a stable dose ≥4 weeks prior to the baseline visit of a medium-to-high dose ICS (fluticasone propionate ≥250 to 1000 μg twice daily \[BID\] or equivalent) in combination with at least a second controller medication (eg, long-acting beta agonist \[LABA\], long-acting muscarinic antagonist \[LAMA\], leukotriene receptor antagonist \[LTRA\], theophylline, etc.); a third controller is allowed and with the same stabilization requirements * Blood eosinophil count ≥300 cells/μL for patients not on maintenance OCS at the screening visit * ACQ-5 score ≥1.5 at the screening and baseline visits Key Exclusion Criteria: * Body mass index \>35 kg/m2 at screening * Current smoking, vaping or tobacco chewing or cessation of any of these within 6 months prior to randomization, or \>10 pack years smoking history * Patients who require supplemental oxygen at screening * Clinically significant cardiac disease as described in the protocol * Uncontrolled hypertension at screening or baseline * Participation in exercise or physical rehabilitation program within last 6 months prior to screening or planned during the study * Previous use of dupilumab * Anti-IgE therapy (eg, omalizumab \[Xolair®\]) within 130 days prior to visit 1 or any other biologic therapy (including anti-IL5, anti-IL-5R, anti-IL4Rα, anti-IL-13 mAb) or systemic immunosuppressant (eg, methotrexate, any anti-tumor necrosis factor mAbs, Janus kinase inhibitors, B- and/or T-cell targeted immunosuppressive therapies) to treat inflammatory disease or autoimmune disease (eg, rheumatoid arthritis, inflammatory bowel disease, primary biliary cirrhosis, systemic lupus erythematosus, multiple sclerosis) and other diseases, within 3 months or 5 half-lives prior to screening, whichever is longer * Exposure to another investigative drug (monoclonal antibodies as well as small molecules) within a period prior to screening, of \<3 months or \<5 half-lives (whichever is longer) * Pregnant or breastfeeding women, or women planning to become pregnant or breastfeed during the study * Women of childbearing potential (WOCBP)\* who are unwilling to practice highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 12 weeks after the last dose NOTE: Other protocol defined inclusion/exclusion criteria apply