In this study the investigators seek to prospectively measure the response of ocular graft-versus-host disease (GVHD) patients to treatment with topical Vigamox. The investigators will accomplish this by enrolling patients with bilateral ocular GVHD and treating one eye with topical Vigamox and the other eye with a placebo eye drop. By assessing the response to treatment with Vigamox, the investigators hope to identify a role for topical antibiotic treatment in ocular GVHD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Change in Ocular comfort
* Ocular comfort will be rated by the participant for each eye on a 0-10 Visual Analog Scale * 0=no discomfort and 10=worst discomfort
Time frame: First clinic visit through second clinic visit (estimated to be 9-14 days)
Change in Ocular Surface Disease Index (OSDI) score
* 12 questions with answers ranging from 0=none of the time to 4=all of the time * The OSDI©is assessed on a scale of 0 to 100, with higher scores representing greater disability. The index demonstrates sensitivity and specificity in distinguishing between normal subjects and patients with dry eye disease.
Time frame: First clinic visit through second clinic visit (estimated to be 9-14 days)
Change in Visual acuity
Time frame: First clinic visit through second clinic visit (estimated to be 9-14 days)
Change in the Degree of Conjunctival injection
-The degree of conjunctival injection will be graded based on the Validated Bulbar Redness scale
Time frame: First clinic visit through second clinic visit (estimated to be 9-14 days)
Change in Corneal/conjunctival punctate epithelial erosions
* The clinical exam will be conducted using the National Eye Institute Fluorescein Staining Scale to grade the degree of corneal and conjunctival stain with a cobalt blue slit lamp filter * This test divides the cornea into 5 sections. Staining is graded on a scale of 0-3, with 0 indicating absence of staining and 3 indicating severe staining.
Time frame: First clinic visit through second clinic visit (estimated to be 9-14 days)
Change in Culture results
-Conjunctival bacterial cultures will be obtained via swab before and after treatment
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: First clinic visit through second clinic visit (estimated to be 9-14 days)