Deep vs Moderate Neuromuscular Blocks on Remifentanil for Laparoscopic Gastrectomy

N/ACompletedNCT04205097

Ajou University School of Medicine120 enrolled

Overview

The primary purpose is to compare the remifentanil requirements in deep vs moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic gastrectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

120

Conditions

Gastric Cancer

Interventions

Neostigmine + glycopyrateDRUG

maintaining of moderate neuromuscular block (train-of-four count 1-2) during surgery, reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg

SugammadexDRUG

maintaining of deep neuromuscular block (posttetanic count 1-2) during surgery, reversal using sugammadex 2-4 mg/kg

Eligibility

Sex: ALLMin age: 19 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of gastric cancer Scheduled laparoscopic gastrectomy Exclusion Criteria: * Patients refusal to consent Hyperbilirubinemia Chronic pain Opioid abuse Incurrent infective status Peripheral vascular disease

Locations (1)

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine

Suwon, Gyeonggido, South Korea

Outcomes

Primary Outcomes

total dose of remifentanil

remifentanil infusion using target effect-site concentration to achieve an surgical pleth index of range between 20 and 50

Time frame: from pneumoperitoneum to removal of laparoscope

Data from ClinicalTrials.gov

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