The aim of this study is to explore if an already established diet with anti-inflammatory effect in paediatric inflammatory bowel disease would have an anti-inflammatory effect in children with JIA. The diet is called specific carbohydrate diet.
Children classified with JIA, in a low-to-medium disease activity and without having changed DMARD or bDMARD in the last 12 weeks are included. Only motivated children and parents can participate. Before inclusion the family are informed orally about the study plan, the diet and practical issues regarding the study and they receive written information including for example a product list and a recipe booklet. A dietician and the principal investigator follows the child and parents during visits, by mail and phone. After the baseline visit, the family has two weeks to get used to the new diet. At baseline, after two, four and twelve weeks on the diet the child is examined, blood exams are performed and blood is stored at -70, fecal samples and urine is also collected. At inclusion and after four weeks saliva sample for bacteria is collected. The child fills in the child health assessment questionnaire, (CHAQ) for a score of the physical ability and DisabKids for an overall assessment of the childs well-being.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Specific carbohydrate diet (see arm description)
Unit of Pediatric Rheumatology, Akademiska hospital
Uppsala, Sweden
RECRUITINGChange in number of inflamed joints
Physical examination
Time frame: At baseline compared to four weeks of intervention
Change in CHAQ, child health assessment questionnaire
A questionnaire for assessment of physical function, min-max, 0-3. A higher score means worse physical function
Time frame: At baseline compared to four weeks of intervention
Change in overall well-being
Global assessment visual analogue scale (VAS), for the patient min-max, 0-10 cm. A higher score means worse overall well-being
Time frame: At baseline compared to four weeks of intervention
Change in assessment of pain: visual analogue scale
Global assessment visual analogue scale (VAS) for Pain, min-max, 0-10 cm. A higher score means more pain
Time frame: At baseline compared to four weeks of intervention
Change in assessment of morning stiffness
Number of minutes
Time frame: At baseline compared to four weeks of intervention
Change in Microbiota in fecal samples
16sSrRNA and Metagenomics
Time frame: At baseline compared to four weeks of intervention
Change in Short chain fatty acids in fecal samples
Analysed, using a HPLC-machine, Agilent technology 1100-series, presented in mg/gr
Time frame: At baseline compared to four weeks of intervention
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