Hemophilia and Bone Metabolism: Study of Monocytic Populations and Inflammatory Proteins

Inclusion Criteria: * Major patients followed at the hemophilia treatment reference center, * Presenting the diagnosis of severe, moderate or minor Hemophilia A / B, * Having a social security system, * Obtaining the oral non-objection collection from the patient after information. Exclusion Criteria: * Minor patients, under guardianship or curatorship. * Causes of secondary osteoporosis: * Systemic corticosteroid therapy in progress (≥ 3 consecutive months, at a dosage ≥ 7.5 mg / d of prednisone equivalent). * other treatment or condition responsible for osteoporosis: prolonged or medicated hypogonadism, untreated active hyperthyroidism, hypercorticism, primary hyperparathyroidism. * Treatment with biphosphonates, biotherapies or hormone therapy in the treatment of prostate cancer.