The study aims to assess the effect of spinal anaesthesia against a general anaesthesia with a femoral block, with respect to the incidence of chronic pain following a total knee replacement. It will also focus on genetic factors and their influence on chronic pain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
200
Patients will receive a spinal anaesthetic
patients will receive a general anaesthetic and a femoral nerve block
Mater Dei Hospital
Msida, Malta
Pain Numerical Rating Scale on physiotherapy
Pain Numerical Rating Scale, from 0 (no pain) to 10 (severe pain)
Time frame: 24 hours
WOMAC Score at 3 and at 6 months
WOMAC score, ranging from 0 to 94
Time frame: 6 months
WOMAC Pain Score at 3 and at 6 months
WOMAC Pain score, ranging from 0 (no pain) to 20 (severe pain on numerous activities)
Time frame: 6 months
Morphine consumption
Morphine use postop
Time frame: 24 hours
Pain Numerical Rating Scale after 6 months
Pain Numerical Rating Scale at rest, from 0 (no pain) to 10 (severe pain)
Time frame: 6 months
Incidence of Chronic Post-surgical Pain
WOMAC pain score greater than 5 at 6 months (out of total of 20)
Time frame: 6 months
Change in WOMAC Score at 3 and at 6 months
change in WOMAC score, ranging from 0 to 94
Time frame: 6 months
Change in WOMAC Pain Score at 3 and at 6 months
change in WOMAC Pain score, ranging from 0 (no pain) to 20 (severe pain on numerous activities)
Time frame: 6 months
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