Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging

N/AUnknownNCT04207502

Chang Gung Memorial Hospital100 enrolled

Overview

This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.

This project is the pilot for the basis of establishing the schema of database and efficient procedures including subject recruitment, specimen collection, management, and measurement of samples obtained from multiple sources. We will focus on deciphering the correlation of sleep quality and the integrity of brain structure by integrating the holistic health data, socio-demographic characteristics, MRI, wearable technique, and laboratory technology including clinical lab, genotyping, metabolomics, gut microbiome, to unravel the clinical feature of which the age will effect on the frequency of sleep disturbance. This project will not only systematically study the aging effect on the sleep quality and brain structure integrity, but pave the way for exploring a variety of aging-related indications.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sleep Disturbance Cognitive Change Aging

Eligibility

Sex: ALLMin age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants of annual health checkup conducted by either Taipei city or Chang Gung Health and Culture Village. * aged ≧ 60 years old. * have medical record in Chang Gung Memorial Hospital. * resided in the Taiwan area over 180 days in past one year. Exclusion Criteria: * Participants with the medical history of severe organ disorders, severe autoimmune disease, or cancer under treatment. * Contraindications or previously failure for receiving brain computerized tomography or magnetic resonance imaging scan. * Participants who had receive outpatient clinic follow-ups with diseases that may affect the cognitive evaluation or presentation. * Depression with ongoing diagnosis and treatment, suicide idea or suicide behavior in the past 6 months. * Difficulty in communication or disabilities

Locations (2)

Taipei Chang Gung Memorial Hospital

Taipei, Taiwan

RECRUITING

Chang Gung Health and Culture Village

Taoyuan City, Taiwan

RECRUITING

Outcomes

Primary Outcomes

The brain volume of local Taiwanese aged over 60 years old

Measure the volume of cerebrum, cerebellum, and skin of skull (unit in mm3) by magnetic resonance imaging (MRI)

Time frame: one hour

The monitoring of sleep-related events of local Taiwanese aged over 60 years old

Measure the sleep stages (unit in minute), apnea-hypopnea index (unit in counts/hour), and respiratory events by polysomnography

Time frame: one night

Secondary Outcomes

The actigraphy of local Taiwanese aged over 60 years old

Measure the circadian rhythm (unit in minute) by Actiwatch

Time frame: two weeks

The neurocognitive questionnaire of local Taiwanese aged over 60 years old

Measure the neurocognitive condition and sleep quality as assessed by GDS-15, UCLA-LS, HAM-A, HAM-D, AES, TSII, CTQ, AD8, MMSE, ECog, CERAD-NAB, PSQI, ESS, SOS, and STOP-Bang

Time frame: one day

The gut microbiota of local Taiwanese aged over 60 years old

Assess the gut bacterial diversity and profile by stool analysis

Time frame: one day

The metabolism of local Taiwanese aged over 60 years old

Measure the metabolites as biomarkers by urine and blood analysis

Time frame: one day

The polysomnographic recording for elderly with obstructive sleep apnea (OSA)

Subjects with OSA will undergo continuous positive airway pressure (CPAP) and evaluate the improvement rate (unit in percent) by polysomnography and sleepiness questionnaire

Central Contacts

JI-TSENG FANG, M.D.

CONTACT

+886-3-3281200 fangjits@cgmh.org.tw

Data from ClinicalTrials.gov

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