The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer

Phase 2CompletedNCT04208334

Phramongkutklao College of Medicine and Hospital20 enrolled

Overview

A study of Curcumin to prevent cancer anorexia and cachexia Syndrom in locally advance and advance stage head and neck cancer (stage III, IV)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Cancer Cachexia Head and Neck Cancer Head and Neck Neoplasms

Interventions

CurcuminDIETARY_SUPPLEMENT

We give an Intervention arm to consume Curcumin 4000mg/day for 60 consecutive days.

PlaceboOTHER

We give a control arm to consume placebo for 60 consecutive days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Head and neck cancer stage III-IV * Cancer anorexia cachexia syndrome by 2011 Cancer cachexia an International Consensus * Enteral feeding with Nasogastric Tube or Gastrostomy * ECOG 0-2 * Normal Bone marrow, kidneys, and liver function * Normal function of enteral digestion and absorption Exclusion Criteria: * Pregnancy * History of allergy to Curcumin or herbal medicine * History of Herbal medicine used * History of Billiary of obstruction * History of Antiplatelete or anticoagulant.

Locations (1)

Phramongkutklao Hospital

Ratchathewi, Bangkok, Thailand

Outcomes

Primary Outcomes

Muscle mass

We measure muscle mass by Bioelectrical Impedance Analysis (BIA)

Time frame: 60 days after intervention

Secondary Outcomes

BMI

We measure BMI by Bioelectrical Impedance Analysis (BIA)

Time frame: 60 days after intervention

Hand grips muscle strength

We measure hand grips power by Hand grip test

Time frame: 60 days after intervention

serum NF-kB level

We measure serum NF-kB by ELISA

Time frame: 60 days after intervention

Data from ClinicalTrials.gov

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