Thyroid disorders are most commonly concomitant with prematurity and still remains a controversial topic. The incidence of a temporary form of hypothyroidism among preterm neonates is higher than in the general population. Transient prematurity hypothyroxinemia is defined as a temporary reduction in FT4 values without increase in TSH values. Currently, there is no consensus about normal thyrotropine (TSH) and free thyroxine (FT4) values in preterm infants. The aim of this study is to determine the volume of the thyroid gland in preterm infants born between 24 and 32 weeks of gestation inborn or admitted to the unit within 14 days from birth and compare it with the results of TSH and FT4 blood concentration. Besides, the objective of the study is to determine values of thyroid hormones in premature infants born before 33 wk gestation to help neonatologist to interpreter the thyroid hormone results
Thyroid disorders are most commonly concomitant with prematurity and still remains a controversial topic. Preterm infants are susceptible to thyroid disorders due to many reasons including immaturity of hypothalamopituitary-thyroid axis, non-thyroidal illness, impaired synthesis and metabolism of thyroid hormones, medication administration like dopamine, steroids, caffeine.The incidence of a temporary form of hypothyroidism among preterm neonates is higher than in the general population. Transient prematurity hypothyroxinemia is defined as a temporary reduction in FT4 values without increase in TSH values. It is a diagnostic challenge in order to differentiate it from thyroid disfunction in the critically ill patient. Currently, there is no consensus about normal thyrotropine (TSH) and free thyroxine (FT4) values in preterm infants. Given the delayed appearance of TSH value increase in preterm newborns additional thyroid evaluation methods are sought. We believe the thyroid ultrasound might prove helpful. The aim of this study is to determine the volume of the thyroid gland in preterm infants born between 24 and 32 weeks of gestation inborn or admitted to the unit within 14 days from birth and compare it with the results of TSH and FT4 blood concentration. We will performed the thyroid ultrasound to estimate the thyroid volume to aid in the comparative evaluation of infants with suspected thyroid disease. The value of sonography thyroid volume will give specialists possibility to identify a gland as normal, small or enlarged. Besides, the objective of the study is to determine value of thyroid hormones in premature infants born before 33 wk gestation to help neonatologist to interpreter the thyroid hormone results
Study Type
OBSERVATIONAL
Enrollment
200
After meeting enrolment criteria the thyroid ultrasound will be performed at 32 and 36 weeks of gestation, blood test for TSH and FT4 will be obtained at 14-21 day of life, at 32 and 36 weeks of gestation
Department of Neonatology and Neonatal Intensive Care Warsaw Medical University
Warsaw, Poland
RECRUITINGDepartment of Neonatology and Neonatal Intensive Care Warsaw Medical University
Warsaw, Poland
NOT_YET_RECRUITINGDetermination of FT4 and TSH values in preterm infants born at 24-28 weeks of gestation
FT4 and TSH - blood concentration
Time frame: 14-21 days of life, at 32 and 36 weeks of PCA
Determination of FT4 and TSH values in preterm infants born at 29-32 weeks of gestation
FT4 and TSH - blood concentration
Time frame: at 14-21 day of life, at 32 and 36 weeks of PCA
Determination of ultrasound thyroid volume in both groups of preterm infants (i.e., those born at 24-28 weeks of gestation and those born at 29-32 weeks of gestation)
The thyroid volume
Time frame: at 32 and 36 weeks of PCA
Evaluation of correlations between circulating thyroid hormone concentrations and thyroid volume
comparison of values of FT4, TSH and thyroid volume
Time frame: at 32 and 36 weeks of PCA
Comparison of changes in FT4 evaluated at 32 and 36 weeks of PCA in each group of preterm infants
comparison of results
Time frame: at 14-21 day of life, at 32 and 36 weeks of PCA
Comparison of changes in TSH evaluated at 32 and 36 weeks of PCA in each group of preterm infants
comparison of results
Time frame: 14-21 days of life, at 32 and 36 weeks of PCA
Analysis of TSH values over time (to determine the optimal time for TSH measurement)
Intervention time
Time frame: at 14-21 day of life, at 32 and 36 weeks of PCA
Evaluation of changes in ultrasound thyroid volume examined at 32 and 36 weeks of PCA in each group of preterm infants
comparison of results
Time frame: at 32 and 36 weeks of PCA
Evaluation of the correlation between thyroid volume and circulating thyroid hormone concentrations with the head circumference and body mass at 32 and 36 weeks of PCA
correlation of results with the body mass and the head circumference
Time frame: at 32 and 36 weeks of PCA
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