Detection of Subclinical Enthesitis by Ultrasonography

N/ACompletedNCT04209894

Fatih Sultan Mehmet Training and Research Hospital61 enrolled

Overview

Detection of subclinical enthesitis by ultrasonography

A total of 30 patients with psoriasis and 30 age-matched healthy controls, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded ultrasound (US) evaluation. Clinical assessment included demographics, severity of psoriasis and musculoskeletal clinical examination. Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Enthesitis

Interventions

UltrasoundDIAGNOSTIC_TEST

Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas of participants. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age≥18years * Patients with psoriasis without musculoskeletal symptoms * Healthy controls * No joint involvement and no clinical symptoms and signs of enthesitis and synovitis Exclusion Criteria: * Have history of gout or arthritis or peripheral neurological disease of lower extremity. * Have history of trauma and intensive sport activity in last 2 weeks. * Have received any systemic therapy (i.e. DMARD, NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months * Pregnant or breast-feeding

Locations (1)

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, Atasehir, Turkey (Türkiye)

Outcomes

Primary Outcomes

Detection of Subclinical Enthesitis by Ultrasonography in Psoriasis Patients with Psoriasis and Controls: by Ultrasonography; Incidence of Psoriatic Arthritis During Within One 1 Year

Incidence of subclinical enthesitis,To investigate the incidence of subclinical enthesitis in patients with psoriasis

Time frame: 1 year.

Secondary Outcomes

Number of participants with Risk factors of subclinical enthesitis

To find out predictor factors of subclinical enthesitis in patients with psoriasis. To assess increase in enthesis area and PsA incidence, and show a possible relationship with baseline findings in a prospective 1-year follow-up of patients with PsO.

Time frame: 1 year

Data from ClinicalTrials.gov

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