The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery

Yonsei University264 enrolled

Overview

In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased. The anti-inflammatory and anti-oxidant effects of vitamin C and the effects of reducing vasoconstrictor use have been demonstrated in patients with sepsis and septic shock, however, the foregoing effects have not been validated in patients undergoing cardiac surgery. In this study, investigators investigate the effect of intravenous vitamin C on the incidence of acute renal injury after valvular heart surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

264

Conditions

Acute Kidney Injury

Interventions

Vitamin C

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients older than 20 years and undergoing elective valvular heart surgery whose preoperative acute renal failure score is ≥3 (moderate to severe risk). Exclusion Criteria: * Emergency operation * Cardiogenic shock or ventricular-assist device (eg. ECMO, IABP) * Severe chronic kidney disease (GFR(CKD-EPI) \<30ml/min/1.73m2) * Patients with past history of gout or renal stone or hyperoxaluria or cystinuria * Hemolytic anemia due to pyruvate kinase deficiency or glucose-6-phosphate dehydrogenase deficiency * Sicklemia or thalassemia * Hemochromatosis * Allergy to disodium ethylenediamine-tetraacetate or ascorbic acid * Patients taking aspirin up to 3 days before surgery * Patients taking antiepileptic drug or fluphenazine or steroid * Patients taking vitamin C within a month of surgery * Pregnant or lactating women * Patients who cannot understand the informed consent (eg. Foreigner)

Locations (1)

Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research Institute, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

Postoperative acute kidney injury

Compare the incidence of postoperative acute kidney injury between the Vitamin C group and the control group according to KDIGO guideline.

Time frame: Postoperative 7 days

Secondary Outcomes

Postoperative oxidative stress and vascular injury(Comparing the serum concentration)

Compare the serum concentration of Malondialdehyde, Thrombomodulin before anesthetic induction and after CPB cessation.

Time frame: Before anesthetic induction (Baseline)