Excessive oxygen administration is known to cause oxidative stress, and absorption atelectasis. Hyperoxia is very common in general anesthesia settings. Even though there are concerns in using excessive oxygen during general anesthesia, the optimal fraction of inspired oxygen (FiO2) for general anesthesia is not well studied. The oxygen reserve index (ORI) is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORI that it might be helpful to reduce hyperoxia in critically ill patients in the intensive care unit, as well as in general anesthesia. The aim of this study is to evaluate efficacy of oxygen reserve index to reduce hyperoxemia in major abdominal surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
64
Titration of fraction of inspired oxygen (FiO2) guided by SpO2
Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2
Kangbuk Samsung Hospital
Seoul, South Korea
Pressure of arterial oxygen (PaO2) after 1 hour of surgery.
Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice.
Time frame: After 1 hour of surgery
Pressure of arterial oxygen (PaO2) after 2 hours of surgery.
Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice.
Time frame: After 2 hours of surgery
Pressure of arterial oxygen (PaO2) after 3 hours of surgery.
Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice.
Time frame: After 3 hours of surgery
Minimal and maximal value of PaO2 throughout the surgery
Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice.
Time frame: 1 hour after the end of surgery
Fraction of inspired oxygen (FiO2)
Fraction of inspired oxygen (FiO2) administered during the surgery
Time frame: 1 hour after the end of surgery
Oxygen reserve index (ORI)
Oxygen reserve idex shown from the monitoring device during the surgery
Time frame: 1 hour after the end of surgery
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