Dexmedetomidine Versus Propofol Sedation in Flexible Bronchoscopy: A Randomized Controlled Trial

Rabin Medical Center100 enrolled

Overview

The study will evaluate clinical outcomes during bronchoscopy procedures with dexmedetomidine in comparison to propofol. The clinical outcomes that will be evaluated are: oxygen saturation, transcutaneous Pco2, blood pressure and complications

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Sedation Complication

Interventions

DexmedetomidineDRUG

Dexmedetomidine will be used for sedation during bronchoscopy

PropofolDRUG

Propofol

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * All patients in the age group 18 to 70 years requiring flexible bronchoscopic evaluation of the airway in the Pulmonary institute at Rabin medical center Exclusion Criteria: * known or suspected allergy to any of the study drugs, seizure disorder, renal (with serum creatinine \> 2 mg/dL) or hepatic impairment (elevated liver enzymes \> 2 times normal), haemodynamic instability (bradycardia with HR \< 50 bpm or hypotension with SBP \< 90 mmHg), or seriously ill patients with American Society of Anesthesiologists' physical status above III

Locations (1)

Rabin Medical Center

Petah Tikva, Israel

RECRUITING

Outcomes

Primary Outcomes

number of de-saturation events

Number of events during bronchoscopy when saturation level decreased under 90%

Time frame: During the procedure

Oxygen saturation time < 90%

Total time during the procedure that the oxygen saturation was under 90%

Time frame: During the procedure

Central Contacts

Barak Pertzov, MD

CONTACT

972548080196 pertzovb@gmail.com

Mordechai Kramer, MD

CONTACT

97239377224 Kremerm@clalit.org.il

Data from ClinicalTrials.gov

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