Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
10
HFNC provides warmed and humidified gas administered through slightly enlarged nasal prongs.
NPPV is the standard therapy for ventilatory failure in AECOPD.
The First Affiliated Hospital of Guangzhou Medical University.
Guangzhou, Guangdong, China
RECRUITINGNeural respiratory drive
Neural respiratory drive is calculated by diaphragm electromyogram
Time frame: 30 minutes
Work of breathing
Work of breathing is calculated by the transdiaphragmatic pressure
Time frame: 30 minutes
Transcutaneous CO2
Transcutaneous CO2 is a non-invasive method estimated the partial pressure of arterial blood CO2.
Time frame: 30 minutes
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