Functional Decline and QoL in People Aging with HIV in Asia

Chinese University of Hong Kong1,500 enrolled

Overview

This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people living with HIV (PLWH) in Asia.

This research project is expected to have the following clinical impact 1. To understand the impact of impaired functional status in PLWH in Asia would be important to determine the long-term health burden needs in this aging population in this part of the world. 2. The identification of risk factors associated with impaired functional status would be important to guide clinical decisions in patient management, such as the choice of anti-retroviral regimen, and screening of and early intervention for modifiable risk factors. These are of paramount importance in the promotion of healthy aging in this population. 3. This proposed cross-sectional study lays the foundation for the establishment of a longitudinal cohort for long-term follow up of people aging with HIV in Asia, with the objectives of evaluating the long-term impact of aging on clinical outcomes and functional status in PLWH in this region.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Frailty Disability Physical HIV/AIDS

Eligibility

Sex: ALLMin age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * HIV antibody positive * Age 35 years or above * Asian ethnicity, including but not limited to Chinese, Malay and Indian Exclusion Criteria: * Inability or refusal to consent * Active infections requiring in-hospital treatment

Locations (2)

Prince of Wales Hospital

Hong Kong, Hong Kong

Prince of Wales Hospital

Shatin, Hong Kong

Outcomes

Primary Outcomes

Functional disability

Functional disability is defined as any difficulty in any of the six areas of functioning in daily life as assessed by WHO DAS II questionnaire

Time frame: 24 months

Secondary Outcomes

Composite score for intrinsic capacity

The score is based on (i) self-reported questions assessing the subjects' eight health domains, including mobility, self-care, cognition, interpersonal activities, vision, pain and discomfort, sleep and energy, and affect, and (ii) measures of grip strength, short physical performance battery and cognitive function

Time frame: 24 months

Physical performance

Physical performance is measured by six-metre usual gait speed. Low physical performance is defined as usual gait speed ≤0.8 m/s

Time frame: 24 months

Cognitive decline

Cognitive decline is defined as presence of HIV-associated neurocognitive disorder (HAND) according to "Frascati Criteria". Asymptomatic neurocognitive impairment (ANI) involves impairment of cognitive functioning in at least two ability domains, in the absence of interference in everyday functioning. Mild neurocognitive disorder (MND) also involves impairment in at least two ability domains, with at least mild interference in daily functioning. HIV-associated dementia (HAD) requires marked impairment in cognitive functioning in at least two ability domains, in the presence of marked impairment in day-to-day functioning

Time frame: 24 months

Frailty

Frailty is measured using the frailty index

Time frame: 24 months

Sarcopenia

Sarcopenia is defined as height-adjusted skeletal muscle mass \<7.0 kg/m2 in men and 5.7 kg/m2 in women using BIA

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.