Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage

Cairo University200 enrolled

Overview

This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

200

Conditions

Missed Abortion

Interventions

letrozole then misoprostolDRUG

Drug: Letrozole 2.5mg total dose 7.5 mg per day for 3 days Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion

placebo then misoprostolDRUG

Drug: Placebo placebo for 3 days Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age less than 64 days gestation (\<9 wks). * Hemoglobin \>10 g/dL. * BMI between 18.5 kg/m2 and 25 kg/m2. * Missed abortion. * previous one or more cesarean delivaries Exclusion Criteria: * Molar pregnancy. * Fibroid uterus. * Uterine anomalies. * Coagulopathy. * Medical disorder that contraindicate induction of abortion (e.g. heart failure). * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or letrozole.

Outcomes

Primary Outcomes

induction to abortion time

Time frame: 6 hours

Incidence of complete miscarriage

Time frame: 6 hours

Secondary Outcomes

Need for surgical evacuation of the products of conception

Time frame: 6 hours

Central Contacts

AHMED SAMY

CONTACT

+201100681167 ahmedsamy8233@gmail.com

Data from ClinicalTrials.gov

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