Efficacy and Safety of a Citrate-based Anticoagulation With Calcium-free Phosphate-containing Fluid in Renal Replacement Therapy

Inclusion Criteria: 1. Acute renal failure requiring CRRT 2. Suitability for regional anticoagulation of the CRRT circuit 3. Clinical equipoise regarding the method of circuit anticoagulation 4. Subject is affiliated with a social security system (if required by individual country regulations). 5. Subject meets national regulatory criteria for clinical trial participation. 6. Subject or subject's Legally Authorized Representative (LAR) has signed the study Informed Consent form Exclusion Criteria: 1. Age less than 18 years 2. Expected stay in ICU less than 24 hours 3. Pregnant or breastfeeding 4. Suspected ischemic hepatitis or liver failure 5. Chronic kidney disease requiring dialysis prior to ICU admission 6. As applicable by French law, subject who is a protected individual such as an incompetent adult or incarcerated person 7. Metformin and acethaminophen intoxication