The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters

Acibadem University22 enrolled

Overview

Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation. Remote organ ischemic preconditioning (RIPC) is one of the most investigated practices to reduce IR injury. In this study, for the first time in the clinic, the effect of RIPC will be evaluated via both systemic inflammation parameters and also parameters showing glycocalyx integrity, on living-donor liver recipients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Remote Organ Ischemic Preconditioning

Interventions

Remote ischemic preconditioningPROCEDURE

An orthopedic tourniquet was tied to the right lower extremities of the patients in RIPC arm, and tourniquet application was performed before the anhepatic phase in 3 periods of 3 minutes with an interval of 3 minutes.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients followed up by Acıbadem Hospital Organ Transplantation Center * Patients accepted to participate in the study * Older than 18 years of age * ASA class III * MELD score \>12 * Scheduled for elective liver transplantation surgery from a living donor Exclusion Criteria: * Patients undergoing re-transplantation * Under the age of 18 years * Patients undergoing emergency surgery * Patients with hepatorenal or hepatopulmonary syndrome * Patients receiving mechanical ventilation support in the ICU * Patients refusing to participate

Locations (1)

Acıbadem Mehmet Ali Aydinlar University Atakent Hospital

Istanbul, Atakent, Turkey (Türkiye)