One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running

University of Worcester9 enrolled

Overview

This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.

Magnesium status can directly affect circulating glucose concentrations both during and post exercise. In addition, magnesium supplementation has been shown to reduce circulating IL-6 concentrations post exercise in humans. It is conceivable that such observations are linked through the role of IL-6 in glucose regulation, possibly in combination with sIL-6R. Together, magnesium intake may have the potential to effect exercise performance and recovery through glucose availability. This in turn may be connected to the production of IL-6 and sIL-6R which have been established to influence exercise fatigue and perception of pain (muscle soreness).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Magnesium Deficiency

Interventions

Magnesium oxideDIETARY_SUPPLEMENT

Magnesium capsule

PlaceboDIETARY_SUPPLEMENT

Cornflour capsule manufactured to mimic the 166.6 mg magnesium capsule.

Eligibility

Sex: MALEMin age: 20 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Regular recreational runner, running around 3 times per week * Capable of running 10 km in \~ 40 minutes. Exclusion Criteria: * Any signs or symptoms of cardiovascular issues. * Any recent form of injury or illness. * Currently, or in the last 3 months, have consumed multivitamin supplements * Currently, or in the last 3 months, have consumed anti-inflammatory medications.

Locations (1)

University of Worcester

Worcester, Worcestershire, United Kingdom

Outcomes

Primary Outcomes

Downhill 10 km treadmill time trial performance

Maximal 10 km time trial performance on a treadmill

Time frame: 1 day

24 hr post exercise maximal force testing of the dominant leg on the isokinetic dynamometer

Maximal force produced from the dominant leg (eccentric and concentric) on an isokinetic dynamometer.

Time frame: 1 day

Secondary Outcomes

Glucose

Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse glucose concentrations.

Time frame: up to 2 days

Interleukin-6

Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse interleukin-6.

Time frame: up to 2 days

Soluble interleukin-6 receptor

Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse soluble interleukin-6.

Time frame: up to 2 days

Perceived muscle soreness

A 10cm visual analogue scale was used to assess perceived muscle soreness, the scale started at 0 (no pain) and finished at 10 (unbearable pain)

Time frame: up to 4 days

Lactate

Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse lactate concentrations.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.