This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.
According to the American college of obstetricians and gynecologists (2005), medical abortion is an acceptable alternative for surgical procedures in pregnant women with gestational age of less than 49 days based on the last menstrual period Oral or vaginal misoprostol causes complete abortion in almost 85% of cases within seven days before the 12th week letrozole administration with misoprostol raises the rate of complete abortion
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
200
total dose 5 mg per day for 3 days then Misoprosrol 800mcg will be given to all patients for induction of abortion
placebo tablets for 3 days then Misoprosrol 800mcg will be given to all patients for induction of abortion
complete abortion rate
Incidence of complete miscarriage
Time frame: 9 hours
time from induction to abortion
induction to abortion time interval
Time frame: 9 hours
Need for surgical evacuation of the products of conception
how many women will undergo dilatation and curettage after failed medical induction of abortion
Time frame: 9 hours
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