Biomaterial-based cell culture models have been gaining increasing attention as potential therapeutic strategies. The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients. Through controllable cell-material interaction, this project has the intention to develop an alternative tool for both early diagnosis and accurate prognosis in cancer therapeutics.
Study Type
OBSERVATIONAL
Enrollment
120
National Taiwan University Hospital
Taipei, Taiwan
RECRUITINGThe correlation between the cell detachment ratio and the overall survival
The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients, hence serve as a prognostic factor for therapeutic strategies. The patient's information required for meta-analysis will be retrieved from medical records, and the log-term follow-up will be conducted.
Time frame: 5-year follow-up after tumor resection
The analyses of the detached cells by specific markers
The isolated and purified patient-derived tumor cells will be characterized by the expression of surface markers using flow cytometry.
Time frame: About one week
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