A Study on the Effect of Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base

N/ACompletedNCT04218591

Karolinska Institutet90 enrolled

Overview

Randomized comparison between Platelet Rich Plasma (PRP) and placebo (Saline) for thumb base.osteoarthritis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Thumb Osteoarthritis

Interventions

PRPOTHER

Platelet rich plasma

PlaceboOTHER

Saline

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Arthritis in the thumb base. * Radiological Eaton Littler class 1-3. * Clinical signs of thumb base osteoarthritis: pain at palpation of the CMC-1 joint and pain during provocation/grinding test. Exclusion Criteria: * Rheumatoid arthritis. * Ongoing infection in the hand or wrist. * History of gout or pseudo gout. * Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction). * Intra-articular injection in the affected joint within 6 months. * Eaton Littler class 4 (STT joint involved).

Locations (1)

Department of Hand Surgery Södersjukhuset

Stockholm, Sweden