Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans

University of Maryland, Baltimore19 enrolled

Overview

The purpose of the research is to find out the effect of commonly used topical antibiotics on the bacteria that live in the nose, throat and on the skin of older adults. In addition, the investigators want to determine if these topical antibiotics affect how bacteria are spread in Community Living Centers of the VA Maryland Health Care System.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Human Microbiome

Interventions

Intranasal Mupirocin and Topical ChlorhexidineDRUG

Antimicrobial antiseptic skin cleanser (4% chlorhexidine) for daily use on Day 1, 3 and 5 of Week 8 of the study. BACTROBAN NASAL ointment (mupirocin calcium ointment, 2%) for use intranasally twice-daily on Day 1, 2, 3, 4 and 5 of Week 8 of the study.

Eligibility

Sex: ALLMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 50 years or older. * Living in a participating nursing home for at least 80% of the past 3 months- * Willing to provide anterior nares, posterior pharynx, skin and throat specimens over the study period. * Willing to use intranasal mupirocin and topical chlorhexidine over a five day period. * Provide signed and dated informed consent from subject or LAR. Exclusion Criteria: * Recent history of MRSA colonization * Use of mupirocin nasal ointment in past 3 months * Use of topical chlorhexidine in past 3 months * History of an allergic reaction to chlorhexidine or mupirocin

Locations (2)

Loch Raven VA Community Living Center

Baltimore, Maryland, United States

Perry Point VA Community Living Center

Perry Point, Maryland, United States

Outcomes

Primary Outcomes

Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization

Change in the abundance of Staphylococcus aureus in the nose from immediately before mupirocin administration to 8 weeks after mupirocin administration.

Time frame: 8 weeks

Change in the Abundance of Staphylococcus Aureus in the Throat After Decolonization

Change in the abundance of Staphylococcus aureus in the throat from immediately before mupirocin administration to 8 weeks after mupirocin administration.

Time frame: 8 weeks

Change in the Abundance of Gram Negative Bacteria on the Subclavian Skin After Decolonization

Quantitative PCR using 16s rRNA is used to quantify the total bacterial load of Gram negative bacteria on the subclavian skin before and after decolonization.

Time frame: 12 months

Change in the Abundance of Gram Negative Bacteria on the Femoral Skin After Decolonization

Quantitative PCR using 16s rRNA is used to quantify the total bacterial load of Gram negative bacteria on the femoral skin before and after decolonization.

Time frame: 12 months

Data from ClinicalTrials.gov

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