Postoperative Cognitive Function and EEG

N/AUnknownNCT04219033

Air Force Military Medical University, China1,250 enrolled

Overview

In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of EEG parameters related to postoperative cognitive dysfunction

Study Type

OBSERVATIONAL

Enrollment

1,250

Conditions

Aging Postoperative Cognitive Dysfunction EEG With Periodic Abnormalities

Interventions

EEG(Electroencephalogram) changeOTHER

patients are found to have characteristic EEG change

Eligibility

Sex: ALLMin age: 65 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. aged 65 and above 2. non-cardiac surgery under general anesthesia; 3. American Society of Anesthesiology(ASA) classification I- II 4. Patients aged 18-40 years old are set as background Exclusion Criteria: 1. patients with central nervous system diseases and mental diseases 2. preoperative minimal mental status examination(MMSE) score\<24; 3. ASA status III or higher 3\) those who have received less than 5 years of education since entering primary school; 4) history of sedatives or antidepressants use; 5) existed or anticipated alcohol or drug abuse(over 40°c and over 100ml per day for the past 3 months); 6) history of surgery within the previous year; 7) those with severe visual or hearing impairment; 8) those participated in other clinical studies within last 3 months;

Locations (18)

Suzhou First People's Hospital

Suzhou, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

The difference of delta wave miss rate between patients with or without cognitive dysfunction by 1 day after surgery

The difference (OR) between the miss rate of delta wave in patients with and without cognitive function change 1 day after operation.

Time frame: from end of surgery to 1 day after surgery

The difference of spindle miss rate between patients with or without cognitive dysfunction by 1day after surgery

The difference (OR) between the miss rate of spindle in patients with and without cognitive function change 1 day after operation.

Time frame: from end of surgery to 1 day after surgery

Secondary Outcomes

The difference of delta wave miss rate between patients with or without cognitive dysfunction by 3 days after surgery

Time frame: from end of surgery to 3 day after surgery

The difference of spindle miss rate between patients with or without cognitive dysfunction by 3 days after surgery

Time frame: from end of surgery to 3 days after surgery

The difference of burst suppression rate between patients with or without cognitive dysfunction by 3 days after surgery

Time frame: from end of surgery to 3 days after surgery

correlation of delta wave miss rate and incidence of postoperative cognitive dysfunction by 1 day after surgery

Time frame: from end of surgery to 1 day after surgery

correlation of delta wave miss rate and incidence of postoperative cognitive dysfunction by 3 days after surgery

Time frame: from end of surgery to 3 days after surgery

Central Contacts

Hailong Dong

CONTACT

862984775337 hldong6@hotmail.com

Zhihong Lu

CONTACT

8613891975018 deerlu23@163.com

Data from ClinicalTrials.gov

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