The Acute Effect of Vaping on Food Intake

N/ACompletedNCT04219189

Virginia Commonwealth University40 enrolled

Overview

This study assesses the acute effects of a standardized 20-minute vaping episode compared to a non-vaping control condition on ad libitum food intake during a 30-minute buffet meal, occurring approximately 45 minutes after the vaping episode

Weight control is a common motive for cigarette smoking and nicotine has been shown to suppress appetite and increase resting metabolic rate, and also serves as a behavioral alternative to eating or a distraction from hunger or food craving. Data on the acute effect of e-cigarette use ('vaping') on ad libitum food intake are non-existent. Given that many e-cigarette users report vaping for weight control and that certain e-cigarettes are being actively marketed for weight management and/or suppression of food cravings, addressing this research gap is of the utmost importance.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Energy Intake Food Intake E-Cig Use Appetite

Interventions

Vaping conditionOTHER

Participants will be asked to use a JUUL device to vape 20 puffs over 20 minutes. Participants will use JUUL pods with \~5% nicotine by weight. The anticipated amount of nicotine that will be absorbed with 20 puffs is approximately 1.6 mg, which is equal to approximately 1.5 cigarettes.

Control conditionOTHER

Participants will have access to an uncharged JUUL device with an empty pod for 20 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 - 65 years of age (ID card verified) * Reports either everyday e-cigarette use with liquid containing at least 0.3% (\~3 mg/ml) nicotine or some day e-cigarette use ( at least 3 days a week) with liquid containing at least 3% (\~30 mg/ml) nicotine for the past 30 days. Exclusion Criteria: * being unwilling to consume the foods provided due to: a) dietary limitations or preferences or b) allergies to the foods provided. * being unwilling to take 20 puffs from a JUUL device containing a 5% nicotine pod * self-reported current, diagnosed medical condition(s) will be excluded automatically: heart-related conditions (e.g., recent heart attack/stroke, coronary heart disease), severe immune system disorders (e.g., HIV/AIDS, multiple sclerosis), respiratory disorders (e.g., COPD, asthma), kidney diseases, liver diseases (e.g., cirrhosis), or seizures * observed high blood pressure at screening (systolic \>140; diastolic \>90) * other self-reported current, diagnosed medical conditions (e.g., specific food allergies, diabetes, thyroid disease, lyme disease) will be considered for exclusion after consultation with the PI and medical monitor * self-reported current, diagnosed psychiatric conditions or who report current psychiatric treatment or psychotropic medication use * past month use of cocaine, opioids, benzodiazepines, methamphetamine, or other (non-cannabis) illicit drugs * self-report of \>25 days out of the past 30 for alcohol use or \>20 days out of the past 30 for cannabis use. * women who are breast-feeding or test positive for pregnancy (by urinalysis at screening) * women using progestin-IUDS for birth control * women using birth control injections (e.g., Depo-Provera) * women who received a hysterectomy and still have ovaries present * self-report intending to quit tobacco/nicotine products in the next 30 days

Locations (1)

Center for the Study of Tobacco Products

Richmond, Virginia, United States

Outcomes

Primary Outcomes

Energy Intake

Energy intake in kilocalories (kcal) during the ad libitum buffet meal will be measured via directly weighed food provision and waste (food/energy intake is calculated by difference).