Electroencephalogram (EEG) and Electroconvulsive Therapy(ECT) Response in Schizophrenia

N/ACompletedNCT04220099

Shanghai Mental Health Center30 enrolled

Overview

This study is designed to find quantitative Electroencephalogram(qEEG) biomarkers to predict Electroconvulsive Therapy(ECT) Response in Schizophrenia

The purpose of this proposal is to explore quantitative Electroencephalogram(qEEG) biomarkers that would predict Electroconvulsive Therapy(ECT) Response in Schizophrenia (SZD). The investigators will recruit 30 SZD patients who are preparing for ECT treatment and assesse psychotic symptoms using Positive and Negative symptom scale(PANSS) before and after 8-sessions clinical course of ECT treatment. These patients needed ECT treatment are assessed by clinicians according to American Psychiatric Association(APA) guidelines. Meanwhile resting EEG will be recorded for 10 minutes before the first episode of ECT treatment. Decrease of PANSS scores will be calculated after the last session of ECT treatment to distinguish responder/non-responder.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Schizophrenia

Interventions

Electroconvulsive therapy(ECT)PROCEDURE

Patients recieve 8-sessions ECT treatments and those kinds of drugs they take since they were recruited remain unchanged during this study.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * DSM-5 criteria for SZD * patients needed ECT treatment assessed by clinicians using American psychological Association(APA) guidelines. * symptoms must be of at least moderate severity (PANSS score \>71) * age between 18 to 60 years old * medications will be stable for at least four weeks prior to ECT, and there will be no dose changes unless medically necessary Exclusion Criteria: * any additional current psychiatric comorbidity * pregnancy or prepare to have a baby * current use of any Antiepileptic drugs * history of taking any kinds of Physicotherapeutics within 6 months * severe psychotic symptoms that make patients could not accomplish the clinical interview

Locations (1)

Shanghai Mental Health Center

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Change in Positive and negative syndrome scale（PANSS）score

It assessed the severity of psychotic symptoms.The responder on PANSS is defined as a PANSS decrease at least 25% from the baseline at post-treatment. PANSS helps us divide cases into response and nonresponse group.

Time frame: up to 4 weeks

EEG functional connectivity difference between response and nonresponse group

This is a predictive indicator collected before ECT treatment. After treatment, we divided 30 patients into response and nonresponse group using PANSS. Then we explore differences in pretreatment EEG functional connectivity at different frequency bands (Alpha, Beta, Delta, and Theta) to find a predictable biomarker for ECT treatment effect.

Time frame: through study completion, an average of 6 months

Data from ClinicalTrials.gov

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