The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.
In recent years, with the development of low-dose chest CT screening, more and more ground glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the early-stage lung adenocarcinoma patients with lung cancer family history have been emerging increasing in recent years in East Asian. This prospective cohort study, with both a cross-sectional and a longitudinal part, will include patients with pulmonary ground glass nodule, which were proven malignant disease. All participants will be asked to complete questionnaire to build the clinical database of GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will be collected as a specific biobank. And the blood samples of other family members of participants will be collected, with their consent and knowledge.
Study Type
OBSERVATIONAL
Enrollment
600
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
RECRUITINGThe prevalence of family aggregation of pulmonary ground glass nodule.
To investigate the aggregation of pulmonary ground glass nodule among first-degree relatives of participants via the questionnaire.
Time frame: 1 week
Susceptibility genetic events related to the family aggregation of ground glass nodules.
To investigate the underlying susceptibility genetic loci which concern with familial inheritance of ground glass nodule.
Time frame: 1 month
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