Different β -Blockers in STEMI and Primary PCI

Inclusion Criteria: * Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes; * Age ≥18 years; * Informed consent from patient or next of kin. Exclusion Criteria: * Nonischaemic Cardiomyopathy; * Cardiac surgery planed in the 6 months; * Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation); * Renal or hepatic failure; * Malignancy, HIV, or central nervous system disorder; * Cardiopulmonary resuscitation \>15 min and compromised level of consciousness; * Cardiogenic shock; * Current participation in any research study involving investigational drugs or devices; * No written consensus; * Previous myocardial infarction.