Food Oral Immunotherapy for Peanut Allergy

Inclusion Criteria: * Individuals between 6 months and 65 years of age with a diagnosis of immunoglobulin E (IgE)-mediated peanut allergy and their caregivers; a diagnosis of IgE-mediated peanut allergy is defined by: (1) documented history of peanut allergy or determined to be allergic by oral food challenge; (2) evidence of peanut-specific IgE by either: positive skin prick test to peanut allergen (reaction wheal at least 3 mm larger than saline control) or serum peanut-specific IgE \> 0.34 kilo-unit/liter (kU/L) or international unit/milliliter (IU/mL) at screening visit * Referral by Massachusetts General Hospital (MGH) allergist for food oral immunotherapy * Willing to sign informed consent or whose caregiver is willing to sign the informed consent (age appropriate) * Willing to sign the assent form, if age appropriate Exclusion Criteria: * History of severe or life-threatening episode of anaphylaxis or anaphylactic shock within 60 days of screening * Severe or poorly controlled asthma * Diagnosis of other severe or complicating medical problems, including autoimmune or chronic immune inflammatory conditions or gastrointestinal inflammatory conditions, such as inflammatory bowel diseases and eosinophilic gastrointestinal disorders * Current use of beta blocker medication(s) * Inability to cooperate with and/or perform oral food challenge procedures * Females who are pregnant, planning to become pregnant, or breastfeeding * Investigator determination of safety concern for any reason