Innovative Functional Food Based on Apulian Lens Culinaris for Contrasting Sarcopenia in Dialysis Patients

Inclusion Criteria: * patients \> 60 years old * omnivore controlled normocaloric diet (30 Kcal/kg ideal weight) * patients with chronic kidney disease (CKD) and routine hemodialysis or peritoneal dialysis * patients with primary sarcopenia identified with score ≥ 4 at SARC-F Questionnaire * informed consent signed Exclusion Criteria: * participation to another clinical trial * limb removal by amputation * altered blood sugar level (HbA1c\>8.0%) or type I diabetes mellitus * neoplastic events in the last 5 years * gut, systemic or autoimmune chronic inflammatory pathologies * use of antibiotics or probiotics up to 30 days prior to recruitment * life expectancy of less than one year * treatment with corticosteroids or immunosuppressive drugs (excluded prednisone at dose \<5 mg at day) * positivity to hepatitis B and C virus, HIV1/2 and syphilis * oxygen saturation in the blood at rest \<93% * alcohol or drug abuse in the last 3 years * clinically important alterations of the following laboratory parameters: hemoglobin \<9.0 g / dL, white blood cells \<2.500 / μl, platelet count \<100.000 / μl, AST and ALT\> 3 times the upper limit of the norm, coagulopathy (INR\> 1.3 ) not due to a reversible cause (eg Warfarin and / or factor Xa inhibitors) * uncontrolled hypertension (resting systolic blood pressure\> 180 mmHg or diastolic blood pressure\> 110 mmHg) * unstable angina pectoris, severe peripheral artery disease, coronary bypass surgery, angioplasty or acute major cardiocirculatory diseases in the previous 3 months * definite congestive heart failure class III or IV (NYHS) or ejection fraction \<25% * severe pulmonary dysfunction: acute exacerbation of chronic obstructive pulmonary disease in phase III or IV (Gold classification) and / or PaO2 levels \<60 mmHg * significant intestinal malabsorption due to partial ileal bypass or other causes * score ≤ 24 at the Mini Mental State Examination (MMSE) or presence of cognitive or linguistic limits that prohibit informed consent or possible elements of study * diagnosis of disabling neurological disorder, including Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, cerebrovascular accident with residual deficits (for example, muscle weakness or gait disorder), dementia or any psychiatric condition that reduces protocol compliance * have a history or evidence of any condition, therapy, laboratory abnormality or other circumstances that could confuse the results of the study or interfere with the patient's participation throughout the duration of the study