Non-intrusive Detection of Temporary Neurologic Impairment By Opioids

Mayo Clinic14 enrolled

Overview

Research is being conducted to better understand the physiologic effects (relating to the action of a drug when taken by a healthy person) of opioid use on oculomotor (relating to the motion of the eye) dynamics and to identify the presence of characteristics consistent with a specific drug or class of drugs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

OxycodoneDRUG

5 mg tablet

PlaceboDRUG

Oxycodone-matched placebo tablet

EyeLink 1000 PlusDEVICE

Non-invasive video-based eye tracking system

Oculo-Cognitive Addition test (OCAT)

Eligibility

Sex: ALLMin age: 21 YearsMax age: 59 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants must be able to consent to participate themselves * Be healthy male or non-pregnant female * Must be able to attend in-person sessions at the Mayo Aerospace Medicine and Vestibular Research Laboratory in Scottsdale, AZ. * Have not used opioids during the preceding 30 days * Prior use of opioids for pain management Exclusion Criteria: * Women who are pregnant or breastfeeding. * Women who are not practicing an effective form of contraception (condoms, IUD, birth control pill, diaphragm), * Past or current history of drug or substance use. * Significant ocular disorder. * Positive drug test for marijuana, opioids, methamphetamines, cocaine, PCP or other controlled substances. * History of use of psychoactive drugs within the past 30 days. * Subjects with a history of cardiopulmonary disease including but not limited to congestive heart failure, obstructive sleep apnea, restrictive lung disease, COPD, moderate to severe asthma and oxygen dependency. * Subjects currently taking sedatives (including benzodiazepines), muscle relaxants or disassociatives.

Locations (1)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States