CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and mortality as well as impaired quality of life. Participants of this study all have severe CKD, defined as estimated glomerular filtration rate \< 30 ml/min per 1.73 m\^2. Stress ergometry, echocardiography, ultrasound assessment of arterial intima-media thickness, lateral lumbar radiograph, ECG, laboratory tests and quality of life assessment were performed at the baseline of the study and will be repeated during follow-up. Atrial fibrillation and other cardiac arrhythmias as well as pulse wave velocity measurements will be explored. Diet diaries are gathered and analysed. The aim of the study is to identify factors associated with cardiovascular disease, quality of life and mortality in this cohort.
Study Type
OBSERVATIONAL
Enrollment
210
Turku University Hospital
Turku, Finland
Mortality
Time frame: 5 years
Cardiovascular morbidity
Time frame: 5 years
Changes in quality of life
Kidney Disease Quality of Life Short Form (KDQOL-SF) instrument, consisting of 20 subscales (0-100), higher score indicating better quality of life
Time frame: 2 years, 5 years
Number of participants with cardiac arrhythmias
Time frame: 2 years, 5 years
Rate of hospitalizations
Time frame: 2 years, 5 years
Abdominal aortic calcification (AAC) score
Scale 0-24, higher values indicate more calcification
Time frame: 2 years, 5 years
Carotid intima-media thickness
Time frame: 2 years, 5 years
Femoral intima-media thickness
Time frame: 2 years, 5 years
Flow-mediated dilatation of brachial artery
Dilatation at 60 seconds after the release of a cuff with pressure of 250 millimeters of mercury for 4.5 minutes, compared to at rest diameter
Time frame: 2 years, 5 years
Maximal bicycle stress ergometry performance
Mean work load (watts) of the last 4 minutes of exercise, higher values indicating better performance
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Time frame: 2 years, 5 years
Left ventricular hypertrophy
Echocardiography (Interventricular septum thickness, Posterior wall thickness, Left ventricular end-diastolic diameter, Left ventricular mass index)
Time frame: 2 years, 5 years
Cardiac systolic function
Echocardiography (Left ventricular ejection fraction, Left ventricular global longitudinal strain)
Time frame: 2 years, 5 years
Cardiac diastolic function
Echocardiography (ratio of the early to late ventricular filling velocities, ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity)
Time frame: 2 years, 5 years