Diffusion tensor imaging (DTI) is a non-invasive MRI technique offering a functional approach that provides morphological information about the microstructures of the nerve roots. DTI is a widely used neuroimaging technique and is a current topic of research in the field of peripheral nerve imaging. The aim of this work is therefore to improve DTI sequences by specifically evaluating the contribution of the multiband technique in healthy volunteers.
For every healthy volunteer will be acquired: * a morphological sequence * a reference diffusion tensor sequence covering three lumbar stages (reference DTI), * a diffusion tensor sequence acquired in multiband technique, covering three lumbar stages (optimized DTI), * a diffusion tensor sequence acquired in a multiband technique, covering a lumbar stage, of higher spatial resolution (centred DTI)
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
Optimisation of DTI sequences in the study of lumbar roots by MRI
Lille Catholic Hospitals
Lomme, France
Image quality measured as signal-to-noise ratio and contrast-to-noise ratio
Comparison of the image quality between DTI optimized and DTI of reference. The signal-to-noise ratio is a measure that compares the level of a desired signal to the level of background noise. Mathematically, the signal-to-noise ratio is the quotient of the (mean) signal intensity measured in a region of interest and the standard deviation of the signal intensity in a region outside the anatomy of the object being imaged. The contrast-to-noise ratio is a measure of image quality based on a contrast rather than the raw signal.
Time frame: Day 0
Fraction of anisotropy and apparent diffusion coefficient
Comparison of fraction of anisotropy, and apparent diffusion coefficient between DTI optimized and DTI of reference. The measurement of fraction of anisotropy, and apparent diffusion coefficient provides robust values for quantifying the degree of microstructural abnormalities of nerves.
Time frame: Day 0
Concordance of observed agreement measured by Cohen's kappa coefficient
Evaluation of interobserver accordance for multiband acquisitions (optimized DTI)
Time frame: Day 0
Concordance of observed agreement measured by Intra-class correlation coefficient
Evaluation of interobserver accordance for multiband acquisitions (optimized DTI)
Time frame: Day 0
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.