This is a randomized controlled clinical trial to investigate the effect of dual trigger (hCG and GnRH agonist) on the final oocyte maturation compared to the standard hCG trigger in patients with poor ovarian reserve seeking IVF/ICSI treatment.
Women with POR (Bologna criteria) manifest a very low follicular response to controlled ovarian stimulation irrespective of the stimulation protocol utilized. Dual triggering of oocyte maturation was shown to improve follicle collection yield and oocyte maturation in women with predicted normal ovarian response. These benefits have been attributed to the GnRHa-induced FSH surge believed to promote oocyte nuclear maturation and cumulus expansion. The aim of the study is to show whether the co-administration of a GnRH agonist and hCG for final oocyte maturation improve oocyte collection and maturation rate
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
140
Dual trigger: human Chorionic Gonadotropin (Choriomon 10,000 IU subcutaneous once) + Gonadotropin-Releasing Hormone agonist (Triptorelin 0.3 mg subcutaneous once)
human Chorionic Gonadotropin (Choriomon 10,000 IU subcutaneous once)
American University of Beirut Medical Center
Beirut, Lebanon
Number of oocytes retrieved (oocyte collection rate)
the total number of oocytes retrieved divided by the number of follicles aspirated (diameter ≥10 mm) on the day of oocyte retrieval
Time frame: 38 hrs
Number of mature oocytes (oocyte maturation rate)
the ratio of MII oocytes to the number of collected oocytes
Time frame: 38 hrs
Fertilization rate
the ratio of normal fertilized oocytes (2PN) to the number of oocytes used for fertilization
Time frame: 48 hrs
Clinical pregnancy rate
the presence of fetal cardiac activity confirmed by transvaginal ultrasound 7 weeks after embryo transfer
Time frame: 7 weeks
Implantation rate
the number of gestational sacs visualized on ultrasound examination divided by the number of embryos transferred
Time frame: 7 weeks
Miscarriage rate
the spontaneous loss of a clinical pregnancy occurring before 12 completed weeks of gestational age
Time frame: 12 weeks
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