Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients

University Hospital, Basel, Switzerland52 enrolled

Overview

In this study, the possible role of serum sodium concentration and its changes on bone markers in hospitalized, hyponatremic patients is determined. Therefore, it is investigated whether in hospitalized, hyponatremic patients the level of carboxy-terminal collagen crosslinks (CTX) is modified by changes in plasma sodium concentration, independently from the aetiology of hyponatremia.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hyponatremia

Interventions

blood samplingOTHER

blood sampling for measurement of bone markers after a fasting period of at least 6 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult hospitalized patients with non-hypertonic hyponatremia: serum sodium \< 130 mmol/l, serum osmolality \< 300 milliosmol /kg * age 18 to 99-year-old * Informed consent as documented by signature Exclusion Criteria: * Severe symptomatic hyponatremia in need of intensive care treatment * Hypertonic hyponatremia with serum osmolality \> 300 mOsm/kg * End of life care (palliative treatment) * End stage kidney disease (dialysis) * Acute liver failure * Wernicke encephalopathy * Hepatic encephalopathy during last 2 months * Hepato-renal syndrome * Any bone disease requiring treatment in the last three years * History of fragility fractures * Pre-menopausal women * Hypogonadism (diagnosed before hospitalization) * Hyperthyroidism * Steroid therapy

Locations (1)

Endocrinology, Diabetes and Metabolism, University Hospital Basel

Basel, Switzerland