Comparative Study for Treatment of Alopecia Areata Using Carboxytherapy and Intralesional Steroids

Kasr El Aini Hospital30 enrolled

Overview

Patients with three lesions of alopecia areata are randomly recruited in this study. Each lesion is randomized in to receiving either carboxytherapy in one lesion, intralesional steroids in another lesion and combination of both in the third lesion. Treatment period is 3 months followed by a follow-up period of 2 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Alopecia Areata

Interventions

CarboxytherapyDEVICE

Carbon dioxide (CO2) gas in injection form

Intralesional Steroid InjectionDRUG

triamcinolone acetonide 8 mg/mL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * early localized scalp alopecia areata * patients who did not receive any medication for at least 2 months before starting the study Patients who agreed to join the study and signed written consent. Exclusion Criteria: * pregnant, and lactating females and those with unrealistic expectation. * Alopecia totalis or universalis or ophiasis or cicatrising alopecia * Usage of systemic treatment of alopecia areata 2 months prior to the study. * Any scalp lesion within the treated area * Bleeding diathesis, severe anemia or platelet disorders * Medical conditions such as autoimmune diseases.

Locations (1)

Kasr ElAiny Hospital, Cairo university

Cairo, El Manial, Egypt

Outcomes

Primary Outcomes

Severity of Alopecia Tool (SALT) score

evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both Minimum value is 0% and maximum value is100% the higher the score the more the hair loss

Time frame: 6months-1 year

Dermoscopy

evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both through counting number dystrophic hair, tapered hair, regrowing hair, black dots, and yellow dots

Time frame: 6months-1 year

blinded observer evaluation by use of photography

evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both

Time frame: 6months-1 year

patient satisfaction rate

evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both

Time frame: 6months-1 year

Data from ClinicalTrials.gov

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