Treatment Phenotypes for Adolescents With Asthma

University of Colorado, Denver80 enrolled

Overview

This study will evaluate how adolescents take their asthma medications using an electronic medication monitor.

This study will look at how adolescents use both their controller and rescue medications using an electronic medication monitoring platform, for the period of one year. Participants will be enrolled in a medication monitoring platform, and their asthma care provider will have access to medication usage information. The study team will collect data on medication use patterns in a real world setting for 12 months per participant. Additionally, healthcare providers will be enrolled in focus groups to determine barriers and facilitators to optimal medication use for their patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Asthma in Children Adherence, Treatment

Interventions

Medication monitoringDEVICE

This is an observational study of medication use patterns. The propeller health device has reminders for controller medication use and gives feedback regarding medication use to the participant, their guardian and their asthma provider

Eligibility

Sex: ALLMin age: 12 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

For adolescent participants: Inclusion Criteria: * Diagnosis of asthma On an inhaled controller and rescue medication for which a propeller health device is available Exclusion Criteria: * Other significant chronic lung disease (from problem list) * Cystic fibrosis * Chronic respiratory failure * Tracheostomy status * Intersititial lung disease * Significant developmental delay * Taking more than 3 asthma related medications * Primary language other than English, Spanish, Catalan, Dutch, French, German or Italian Healthcare providers will be recruited as well to participate in focus groups as part of specific aim 2.

Locations (1)

Childrens Hospital Colorado

Aurora, Colorado, United States

Outcomes

Primary Outcomes

Treatment Phenotypes

The Investigators will calculate the number of participants that fall into the following treatment phenotypes: "Well controlled-good adherence", "Well controlled-poor adherence", "Poorly controlled-good adherence", "Poorly controlled-poor adherence". We had initially planned to report only these 4 groups, however there was a very clear breakdown into 9 groups-as we needed to consider a moderately controlled group and a moderately adherent group. Therefore the groups are reported as follows: Poor Adhrence, Poor control Poor adherence, moderate control poor adherence, good control Moderate adherence, poor control moderate adherence, moderate control moderate adherence, good control good adherence, poor control good adherence, moderate control good adherence, good control The investigators will use group based trajectory modeling to evaluate adherence and control phenotypes

Time frame: 12 months

Secondary Outcomes

Qualitative Information Regarding Barriers for Medication Use

Qualitative data (semistructured interviews with patients regarding barriers to medication use.

Time frame: 12 months

Qualitative Information Regarding Facilitators for Medication Use

Qualitative data (semistructured interviews with adolescents) regarding barriers to medication use.

Time frame: 12 months

Qualitative Information Regarding Facilitators for Medication Use

Qualitative data (focus groups with healthcare providers) to determine facilitators to medication use.

Time frame: 12 months

Qualitative Information Regarding Barriers for Medication Use

Qualitative data (focus groups with healthcare providers) to determine facilitators to medication use.

Time frame: 12 months

Data from ClinicalTrials.gov

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