The Effect of Degree of Rice-polishing on Glycaemic Response

Singapore Institute of Food and Biotechnology Innovation14 enrolled

Overview

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Diabetes Mellitus Obesity

Interventions

Glucose Reference 1OTHER

50 g of glucose dissolved in 250 ml of water (First glucose control visit)

Glucose Reference 2OTHER

50 g of glucose dissolved in 250 ml of water (Second glucose control visit)

Glucose Reference 3OTHER

50 g of glucose dissolved in 250 ml of water (Third glucose control visit)

Eligibility

Sex: MALEMin age: 21 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * Chinese ethnicity * Age ≥21 and ≤ 60 years * Body mass index between 18.5 to 25 kg/m2 * Normal blood pressure =\<140/90 mmHg * Fasting blood glucose \<6.0 mmol/L * In general good health Exclusion Criteria: * Current smoker * Have any metabolic diseases (such as diabetes, hypertension etc) * Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) * Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics) * Have intolerances or allergies to any foods * Currently partake in sports at the competitive and/or endurance levels * Intentionally restrict food intake

Locations (1)

Clinical Nutrition Research Centre

Singapore, Singapore

Outcomes

Primary Outcomes

Glucose

Whole capillary blood glucose will be measure using Hemocue analyser

Time frame: Up to 180 minutes

Secondary Outcomes

Insulin

Capillary plasma will be measure using Cobas analyser

Time frame: Up to 180 minutes

Data from ClinicalTrials.gov

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