Evaluating the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects

Inclusion Criteria: 1. age 18-80, regardless of gender; 2. patients who have undergone DSAEK or DMEK and need to remove corneal epithelium; 3. Schirmer test I ≥10mm/5min; 4. normal corneal limbus structure under slit lamp during screening period; 5. sign the informed consent. Exclusion Criteria: 1. intraocular pressure \> 21mmHg or baseline intraocular pressure \> 35mmHg during screening period; 2. fasting blood glucose \> 9.0mmol/L during screening period; 3. postoperative complications occurred, such as dislocation of the implant and high intraocular pressure caused by air bubbles in the anterior chamber; 4. suffered from eye infection, optic neuritis, pigment membrane inflammation, or fundus, macular lesions that affect vision, glaucoma; 5. serious cardiovascular history (congestive heart failure, uncontrolled hypertension, unstable coronary heart disease or myocardial infarction or severe arrhythmia, etc.); 6. severe hepatic and renal insufficiency, alanine aminotransferase (ALT), alanine aminotransferase (AST) ≥ 2 times the normal upper limit, blood creatinine (Cr) ≥ 1.5 times the normal upper limit; 7. those who wear contact lenses within 3 days before screening; 8. screening drugs that have used corneal repair effect within the first 3 days; 9. have received corneal refractive surgery or keratoplasty; 10. have received internal eye surgery within 3 months before screening or need to undergo internal eye surgery during the study period; 11. have participated in other clinical trials or are participating in other clinical trials within 3 months prior to screening; 12. suffering from central nervous system disease and/or mental state inability to cooperate; 13. women in pregnancy, lactation or childbearing age do not take effective contraceptive measures; 14. allergy to the test product and basic drugs; 15. patients who are not considered appropriate to participate in this study, including those who are unable or unwilling to comply with the protocol requirements.