Trials of Ventilation Assisted Substance Elimination Via the Lung - Ethanol (VASEL - Ethanol)

University Health Network, Toronto40 enrolled

Overview

This prospective, randomized control trial will use passive, isocapnic hyperventilation, applied via the ClearMateTM device (Thornhill Medical, Inc) versus controls receiving standard of care supportive management for severe alcohol intoxication to assess for enhanced ethanol elimination kinetics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Alcohol Intoxication

Interventions

ClearMateTMDEVICE

Passive isocapnic hyperventilation breathing circuit.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * intoxicated requiring admission to an emergency unit Exclusion Criteria: * Liver or renal disease

Outcomes

Primary Outcomes

Alcohol elimination time constant

From the recorded venous ethanol blood alcohol values, an elimination time constant will be calculated

Time frame: 6-24 hours

Data from ClinicalTrials.gov

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